KCl-Depolarization Potentiates the Ca2+Sensitization by Endothelin-1 in Canine Coronary Artery
نویسندگان
چکیده
منابع مشابه
Removal of the endothelium potentiates canine large coronary artery constrictor responses to 5-hydroxytryptamine in vivo.
Recent studies in isolated epicardial coronary artery rings have shown that the endothelium modulates vasomotor responses to certain endogenous neurohumoral agents. It is not known whether the endothelium plays a role in large coronary vasoregulation in the intact coronary circulation. Accordingly, we examined effects of endothelial removal on vasoconstrictor responses of the proximal coronary ...
متن کاملCoronary artery disease diagnosis by analysis of ECG depolarization.
For both men and women, coronary artery disease (CAD) is the leading cause of death in industrialized countries. CAD often shows atypical patterns in women, which makes its diagnosis particularly challenging, and in many instances misleading. Accurate CAD diagnosis is essential to provide appropriate treatment and increase the chances of positive outcome. Traditional non-invasive techniques for...
متن کاملAssociation of Big Endothelin-1 with Coronary Artery Calcification
BACKGROUND The coronary artery calcification (CAC) is clinically considered as one of the important predictors of atherosclerosis. Several studies have confirmed that endothelin-1(ET-1) plays an important role in the process of atherosclerosis formation. The aim of this study was to investigate whether big ET-1 is associated with CAC. METHODS AND RESULTS A total of 510 consecutively admitted ...
متن کاملEndothelin-1-induced depolarization and hyperpolarization in submandibular ganglion neurons.
The effects of endothelin-1 were studied in vitro on neurons in the hamster submandibular ganglion, using the intracellular microelectrode technique. Endothelin (1 microM) caused a depolarization (5.5 +/- 1.2 mV) followed by a hyperpolarization (8.5 +/- 2.8 mV) of the membrane potential. Membrane conductance was increased during the endothelin-induced depolarization and was decreased during the...
متن کاملEndogenous endothelin maintains coronary artery tone by endothelin type A receptor stimulation in patients undergoing coronary arteriography.
OBJECTIVE To examine the contribution of endothelin type A (ET(A)) receptor stimulation by endogenously generated endothelin-1 (ET-1) to the maintenance of coronary vascular tone in humans. DESIGN Controlled clinical study. SETTING Tertiary cardiovascular referral centre. PATIENTS 14 subjects were studied, seven with normal coronary arteries and seven with coronary artery disease, mean (S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1992
ISSN: 0021-5198
DOI: 10.1254/jjp.60.403